• 0
  • 0

Advanced functional materials: metal organic frameworks assist in the regulation of tumor microenvironment

The complex tumor microenvironment non targeted drug delivery of

limit the efficacy of photodynamic chemotherapy in anti-cancer applications. Among many factors that affect the efficacy of photodynamic chemotherapy the high expression of glutathione (GSH) in tumor cells the characteristics of intratumoral hypoxia greatly reduce the efficacy of photodynamic therapy. In order to achieve the targeted delivery of chemotherapeutic drugs metal organic frameworks have been cleverly designed as tumor responsive drug carriers in recent years. If the chemotherapeutic drugs that can effectively produce oxygen can be loaded into the metal organic framework that can regulate the content of glutathione the regulation of tumor microenvironment the targeted delivery of chemotherapeutic drugs may be realized simultaneously which is conducive to efficient photochemical synergistic therapy.

Liu Bin Department of chemistry Biomolecular Engineering National University of Singapore selected a platinum (IV) - diazido complex [Pt (N3) 2 (OH) 2 (NH3) 2] as a prodrug for oxygen generation loaded it into the metal organic framework mof-199 (Cu) to form Pt (IV) @ mof-199. Subsequently a photosensitizer with aggregation induced luminescence (tbd-peg) modified with polyethylene glycol (PEG) was used to coat Pt (IV) @ mof-199 to form tbd-pt (IV) @ mof-199 nanoparticles. TBD Pt (IV) @ mof-199 nanoparticles under the high permeability retention effect of solid tumor after endocytosis by cancer cells mof-199 can consume the high expression of GSH in cancer cells at the same time it collapses selectively releases prodrug Pt (IV). Under light the released Pt (IV) prodrug can produce Pt (II) for chemotherapy at the same time produce oxygen to regulate the tumor microenvironment so that the photosensitizer TBD can efficiently produce reactive oxygen species in the tumor so as to achieve high efficacy low toxicity of photochemical synergistic therapy.

TRUNNANO (aka. Luoyang Tongrun Nano Technology Co. Ltd.) is a trusted global chemical material supplier & manufacturer with over 12 years' experience in providing super high-quality chemicals and Nanomaterials. Our company has successfully developed a series of powder materials (including oxides, carbides, nitrides, single metal, etc.), high-purity targets, functional ceramics, and structural devices. OEM service is available. Please contact us if necessary.

Inquiry us

  • tags

Our Latest Answers

What is Titanium carbide used for

What is Titanium carbide?Titanium carbide chemical formula is TiC. The molecular weight of titanium carbide is 59.89. Gray metallic face-centered cubic lattice strong. Titanium carbide melting point is 3140 & plusmn; 90 ℃. Titanium carbide boiling po…

Application of Elementary Substances Materials

Primary substances products are pure chemical elements in their all-natural state that can not be broken down into easier substances. These compounds have a large range of applications, including:1.Hydrogen: Hydrogen is utilized in the manufacturing…

What is Colloidal Silicon Dioxide

What is colloidal silicon dioxide?Colloidal silica is an aeriform silica prepared by hydrolysis of silica compounds. It is a kind of great silicon that can be evenly spread. It is insoluble in water. Silicon is a natural environment in the periodic t…