Home > Business > Advanced materials: ion exchange between metal organic framework hybrid materials triggered by tumor microenvironment for multimodal imaging and collaborative therapy of tumor

Advanced materials: ion exchange between metal organic framework hybrid materials triggered by tumor microenvironment for multimodal imaging and collaborative therapy of tumor

wallpapers Business 2020-10-04 >

nano diagnostic therapeutic agents (NTAS) with the advantages of visual biological distribution effective tumor enrichment real-time feedback show great potential in personalized cancer treatment. With the progress of nanotechnology NTAS with excellent imaging functions (CT imaging nuclear magnetic resonance imaging photoacoustic imaging etc.) therapeutic capabilities (photothermal therapy photodynamic therapy chemical kinetics therapy etc.) have been developed. However most of the reported NTAS are always in the "on" state when they are circulating in vivo which leads to the poor tumor specificity of NTAS in systemic circulation which seriously restricts the further clinical application of NTAS. In order to reduce background interference at the source increase tumor specificity in situ synthesis of NTAS in tumor tissue has attracted extensive interest of researchers.

aimed at how to realize the in situ synthesis of NTAS in tumor tissue Professor Zhang Xianzheng's research group of Wuhan University designed a kind of nano therapeutic agent precursor (PBAM) based on the rapid ion exchange inside the material to realize the in situ synthesis of NTAS in tumor tissue. The PBAM nanoparticles were composed of mil-100 (FE) - Coated Prussian blue analogue (k2mn [Fe (CN) 6]). Due to the spectral characteristics of mil-100 (FE) k2mn [Fe (CN) 6] PBAM has little absorption in the near infrared region so it has no potential for photoacoustic imaging photothermal therapy. At the same time Mn2 ions are bound by the surrounding cyanogens in the spatial structure so they do not have the ability of T1 weighted magnetic resonance imaging. In the slightly acidic tumor microenvironment mil-100 gradually degraded released Fe3 . Fe3 ions further exchanged with Mn2 ions in k2mn [Fe (CN) 6] to form a photothermal reagent KFE [Fe (CN) 6] released free Mn2 ions which realized the transformation of T1 weighted MRI photoacoustic signal from "off" to "on" thus improving the signal-to-noise ratio of tumor imaging at the source. In vivo animal experiments further show that this strategy can not only perform specific imaging for solid tumors but also has good monitoring effect for invisible metastases. In addition the combination of Mn2 mediated chemokinetic therapy Prussian blue mediated photothermal therapy also ensures the therapeutic effect of tumor.


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