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Advanced optical materials: near infrared two region optical coherence tomography based on high aspect ratio plasmon nanostructures
to solve the above problems the research team of Professor Deng Shaozhi from school of electronic information engineering Sun Yat sen University China prepared a kind of SP silver nano heterostructure with high aspect ratio (> 8) by two-step wet chemical growth method( AgNR@mSiO2 )。 The heterostructure is a core-shell structure: silver nanorods epitaxially grown on gold nanocones are used as the core mesoporous silica coating is used as the shell. Due to its high aspect ratio the SP resonance peak of the heterostructure is located at 1330 nm exhibits a large light scattering cross section (3.7 × 105 Nm2) which is the maximum value of the reported OCT nano contrast agent. At the same time the existence of mesoporous silica shell insulates the silver nanorods from the external environment which makes the heterostructures show excellent biocompatibility stability. On this basis the research team cooperated with Professor Zhou Jianhua's research group of School of Biomedical Engineering Sun Yat sen University to AgNR@mSiO2 Nano heterostructures are used as contrast agents in Oct enhancement imaging. The experimental results of in vitro model imaging show that under the illumination of imaging laser with central wavelength of 1310 nm AgNR@mSiO2 Nano heterostructure can significantly improve the imaging contrast depth of Oct. Furthermore due to the excellent biocompatibility of the heterostructure fish eye chicken arterial blood vessels were used as animal models in vivo high-quality OCT imaging of nir-ii region was also obtained The researchers believe that this study demonstrates the advantages of silver based SP nanostructures as a contrast agent for OCT imaging in nir-ii region thus providing a new idea for the development of high-quality imaging contrast agent for nir-ii region based on scattering imaging.

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