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Advanced therapeutics: emitting more than 1300 nm near infrared fluorescence / photoacoustic reagent for tumor photothermal therapy

wallpapers Business 2020-08-11 >

fluorescence imaging is a new molecular imaging technology developed rapidly in recent years which has the advantages of strong specificity high sensitivity. It has been widely used in chemistry biology medicine other fields. As the key material of fluorescence imaging near infrared organic functional dyes play a very important role. On the one h the near-infrared fluorescence signal has low background interference strong tissue penetration depth which can effectively improve the imaging effect in living organisms tissues; the near-infrared organic functional dyes can be used as photothermal agents to convert light energy into heat energy for non-invasive treatment of tumors. On the other h the combination of near-infrared (nir-i: 700-900 nm; nir-ii: 1000-1700 nm) fluorescent dyes with high spatial resolution ultrasound detection high contrast optical imaging photoacoustic imaging technology can collect molecular information from most tissues greatly improving the specificity penetration depth spatial resolution of tissue imaging. Therefore it is of great significance to develop a long wavelength absorption / emission imaging therapy integrated reagent with high photothermal conversion efficiency low toxicity which can be used for fluorescence / photoacoustic dual-mode accurate imaging of deep tissue imaging guided tumor photothermal therapy. As one of the most commonly used electron acceptors

benzodiazole (BBTD) has been widely used to construct functional nir-ii fluorescent reagents with D-A-D electronic characteristics. However the strongest absorption emission wavelengths of BBTD based fluorescent reagents are still short most of which are around 700-850 nm 1000-1100 nm. Therefore in order to further improve the penetration depth photothermal conversion efficiency of tissue imaging it is imperative to further red shift the absorption emission of fluorescent reagents. To this end Professor Yang Guangfu Professor Yin Jun of central China Normal University proposed a new design strategy of fluorescent probe by comprehensively analyzing the relationship between their molecular structure photophysical properties on the basis of nearly 100 reported cases of BBTD molecules: regulating the electron donor capacity at both ends of BBTD scaffold the flatness of conjugated units to regulate the absorption wavelength fluorescence Shoot. Based on this they have successfully designed synthesized a new NIR fluorescent reagent with the strongest absorption at 942 nm. Its fluorescence coverage area is more than 1500 nm the strongest fluorescence emission reaches 1302 nm which is the farthest BBTD fluorescent probe reported so far. In addition the reagent showed good photothermal effect photoacoustic signal. Then the nanoparticles formed by PEG coating the reagent can be used for in vivo imaging of mice. After intravenous injection the fluorescence signal photoacoustic signal of nir-ii region reached the maximum after 12 h then gradually weakened. In the tumor model the nanoparticles injected through the tail vein can be effectively enriched in the tumor area of mice under 808 nm laser irradiation the tumor can be completely ablated. This study has a good guiding role for the development of nir-ii fluorescent reagents with longer wavelength. The results were published in advanced therapeutics( DOI:10.1002/adtp.202000170 )It's on.

Fengying Ye Weijing Huang Chonglu Li Guangjin Li Wen-Chao Yang Sheng Hua Liu Jun Yin; Yao Sun Guang-Fu Yang. Near-Infrared Fluorescence / Photoacoustic Agent with An Intensifying Optical Performance for Imaging-Guided Effective Photothermal Therapy. Adv. Therap. 2020 2000170.


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